Boehringer Ingelheim to start late-stage hepatitis C drug trial
















BOSTON (Reuters) – Boehringer Ingelheim said on Saturday it plans to initiate a late-stage clinical trial of its experimental hepatitis C treatment following promising results from earlier studies.


The company announced final data from a mid-stage trial of its treatment regimen which showed that 69 percent of patients in the study were free of the virus 12 and 24 weeks following the end of treatment.













Hepatitis C is a blood-borne infectious disease of the liver that can lead to liver failure and transplant.


Historically, hepatitis C has been treated with pegylated interferon and ribavirin, but treatment lasts as long as 48 weeks and interferon is associated with flu-like side effects.


The goal of drugmakers now, including Boehringer, Vertex Pharmaceuticals Inc, Gilead Sciences Inc and Bristol-Myers Squibb Co is to develop products that do not need to be combined with interferon. Most analysts consider Gilead to currently be at the forefront of the race.


Full results from Boehringer’s trial, known as SOUND-C2, were presented at the annual meeting of the American Association for the Study of Liver Diseases in Boston. Preliminary data were presented earlier this year.


Boehringer’s trial tested a combination of BI-201335, a protease inhibitor, BI-207127, a polymerase inhibitor, and ribivirin.


Boehringer is a privately held company headquartered in Ingelheim, Germany.


(Reporting By Toni Clarke; Editing by Marguerita Choy)


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The Workday After Tomorrow
















What happens when business as usual is impossible? When millions in the Northeast lost power, cell service, Internet access, and running water due to Superstorm Sandy, companies scrambled to find the answer. Some improvised on the spot: Keith McNally’s New York City bistro Balthazar grilled steaks and served lobster on Prince Street, while Katz’s Delicatessen sliced up sandwiches by candlelight. Manhattan’s Equinox fitness clubs started a second business, selling showers for $ 35 a pop. Large financial firms such as Goldman Sachs (GS) began relocating staff and workloads from New York to offices overseas, and tens of thousands of workers turned to the cloud, working from home—or Starbucks (SBUX). Meanwhile, Tim Webster, a customer enablement manager at EMaint Enterprises, an info-tech company in Mount Laurel, N.J., found himself in a Florida Wal-Mart (WMT), picking out a Captain America costume for the company’s impromptu Halloween party. “It’s hard to complain,” he says. “I mean, it’s a bit cold this morning. Maybe you need a light jacket?”


Webster was one of five employees flown down to EMaint’s satellite office in Estero, Fla., on the Saturday before Sandy hit, as part of the company’s business continuity plan. “It looked like we were going to get battered here in South Jersey, with mass power outages and trees down, and we have customers worldwide,” says Jon Hollander, executive vice president of operations. “So we decided to send five of our core-function employees for an expense-paid vacation in sunny Florida.”













Thanks to data stored in the cloud, the company was able to provide service to its clients without interruption. But Webster (who insists “it’s not a vacation—I’m still working”) is still playing it safe. “I’m staying out of the sun,” he says, noting how weird it’s been to see his colleagues wearing shorts.


093af  etc opener46  01  inline405 The Workday After TomorrowIllustration by Marcos Chin


World economic losses to disasters totaled an estimated $ 380 billion in 2011, and nearly every major company now sets up detailed continuity and mitigation plans for everything from terrorist incidents and nuclear attacks to pandemics like bird flu. A cottage industry of in-house sky-is-falling professionals and glass-half-empty consulting firms has sprung up to deal with this need. And as companies become more reliant on digital data and geographically diverse locations, their strategies must evolve, too. “For instance, people don’t warehouse parts anymore,” says Ken Burris, chief executive officer of Witt Associates, a crisis management consultancy. “They rely on just-in-time delivery. But when there’s that hiccup in the supply chain, they’d better have multiple contingencies in place, or work stops.” And Burris points out that the implications are often dire: “Statistics show that, of small businesses impacted by disaster, about a third don’t recover.”


The biggest difference between recent disruptions and those only a decade ago shows up in businesses’ increasing faith in cloud computing, which was sorely tested by Sandy. As Lower Manhattan was swamped, major media companies such as Huffington Post, MarketWatch, and Gawker saw their sites go offline as water flooded the basement floors of the Datagram server building. Gawker Media eventually improvised by redirecting Gawker, Gizmodo, and Deadspin to temporary Tumblr blog pages. “If we’re the indestructible cockroaches of the media world,” Gawker founder Nick Denton e-mailed his staff, “now’s the time to show it.” Still, the network lost nearly all its advertising opportunities, save a cheeky “Back Up Site Covered by State Farm” plug at the top of each site’s Tumblr home page.


Peer1 Hosting, a Net outfit based in Lower Manhattan, thought it was in the clear—it had generators on the 17th floor ready to keep the data servers humming. But when the fuel pump in the basement was flooded, Peer1 was unable to get the necessary diesel fuel upstairs. So it improvised, too. “We had a team of 30 people getting buckets of diesel fuel going up 17 floors to keep the generator working and our customers online,” says Rajan Sodhi, Peer1’s vice president of marketing. Employees hoofed it up darkened stairwells for more than 48 hours, replenishing the tanks.


Shawn White, vice president of operations for Keynote Systems, which monitors online access, says many companies have turned to the cloud primarily for cost savings, not safety. “If you’re going to be in the cloud, you have to make sure they have options for multiple data centers in a geographically distributed base. It’s extra money, but that’s the cost of a robust continuity plan,” he says.


And obviously the cloud can’t help if you don’t have electricity, cell service, or Net access. In the 10 states hit by Sandy, 25 percent of cell towers and land lines were affected by the storm, according to the Federal Communications Commission. Downtown New York lost power for nearly a week. “People keep asking what they can do if there is absolutely no power at all, anywhere,” says Ken Moon, co-founder of Connecticut-based emergency software platform Veoci Systems. “I say, ‘It’s smoke signals and CBs, if you got ’em. And how long the juice lasts on your cell phone, if your cell phone works.’”


093af  etc opener46 4051 The Workday After TomorrowClick to enlarge


Throughout the Northeast, many of the contingency plans at businesses failed, most notably at several hospitals, which were left without working backup generators and forced to evacuate patients. Now experts are sorting out why. “This notion that big disasters are wake-up calls?” Irwin Redlener, director of the National Center for Disaster Preparedness, asks. “They’re more like snooze alarms. Everyone gets aroused, then we end up repeating mistakes. For too long we’ve depended upon seat-of-the-pants decision-making to determine disaster policy. We have a lot of data about what actually works.”


So how does a company or government stress the importance of disaster planning when a storm isn’t bearing down? By invoking the undead, of course. “Are You Zombie Safe?” asks a Red Cross video promoting its disaster preparedness training program. The Centers for Disease Control and Prevention published a graphic novel, Preparedness 101: Zombie Pandemic. The Federal Emergency Management Agency and the Department of Homeland Security also have so-called zombie-based safety programs. In fact, while the East Coast scrambled to recover from Sandy, thousands of first responders and security firms were preparing for Zombie Apocalypse, an emergency-response training event held at the Paradise Point Resort in San Diego.


“We get all these first responders in here and tell them the sky is falling, the Mayans were right, the clock is ticking, and your bosses are watching,” says Brad Barker, president and founder of Halo, the event’s organizer. In addition to simulating crisis-driven hysteria, he also dresses up actors as zombies in elaborate Hollywood makeup and orders them to eat the humans’ brains. “We got our asses handed to us during Katrina on live TV, and everyone knows it,” says Barker. “We create hyper-realistic training, so you can put together a plan for a mass casualty event of any kind, whether that’s seismic, meteorological, biological, or somebody flies a couple planes into your building. The zombies just make it fun.”


But what happens when every plan has fallen apart and it’s just you, your cubicle, and a horde of alien, radioactive, bird-flu-infected terrorist zombies? “The priorities of survival are always the same, whatever the terrain or disaster,” says Bear Grylls, celebrity survivalist and host of TV show Man vs. Wild. “Protection, rescue, water, food.” Grylls recommends gathering office trash bags and using them for shelter, water collection, or waterproofing your tinder and cell phone. “Remember, you can only last three days without water, but three weeks without food.” On that last note, Grylls says that even in an office environment (the filthier the better), would-be survivalists should look for “bugs, grubs, and worms before rats or bigger game—as well as the obvious, like vending machines and cans.”


Last (and, yes, least), take a page from such fictional companies as Cyberdyne Systems in the Terminator franchise, Weyland Yatuni in Alien, BuyNLarge in Wall-E, and the Trade Federation of the Star Wars prequels. They’re all extraordinarily evil. So evil, in fact, that in most post-apocalyptic fiction, the company last left standing is usually the one that created the catastrophic calamity in the first place. If the collected wisdom of sci-fi is right, a company’s best long-term disaster preparedness strategy is the opposite of Google’s (GOOG): Be Evil.


Businessweek.com — Top News



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Twin explosions strike southern Syrian city
















BEIRUT (AP) — Syria‘s state-run news agency says two large explosions have struck the southern city of Daraa, causing multiple casualties and heavy material damage.


SANA did not immediately give further information or say what the target of Saturday’s explosions was.













The Britain-based Syrian Observatory for Human Rights says the blasts went off near a branch of the country’s Military Intelligence in Daraa.


The Observatory, which relies on a network of activists on the ground, says the explosions were followed by clashes between regime forces and rebels fighting to topple President Bashar Assad.


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Spotify to raise $100 million at $3 billion valuation – report
















(Reuters) – Spotify is in the middle of a $ 100 million financing round that could value the music streaming company at just over $ 3 billion, the Wall Street Journal reported citing sources.


The Journal said Spotify would raise the fresh capital from multiple investors including Goldman Sachs. The WSJ report did not name any other investors.













Spotify has raised capital from outside investors several times since it set up shop in 2006, and was earlier reported to have been looking to secure a capital boost of about $ 200 million, at a valuation of about $ 4 billion.


Kleiner Perkins Caufield & Byers, Accel Partners and others have invested about $ 189 million in the company in its prior financing rounds.


The company has over 15 million active users and 4 million paying subscribers, for its on-demand service, which offers unlimited music streaming of some 18 million tracks.


(Reporting by Himank Sharma in Bangalore)


Internet News Headlines – Yahoo! News



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Philip Roth says he’s done writing
















NEW YORK (AP) — Exit, Philip Roth? Having conceived everything from turning into a breast to a polio epidemic in his native New Jersey, Roth has apparently given his imagination a rest.


The 79-year-old novelist recently told a French publication, Les inRocks, that his 2010 release “Nemesis” would be his last. Spokeswoman Lori Glazer of Houghton Mifflin Harcourt said Friday that she had spoken with Roth and that he confirmed his remarks. Roth’s literary agent, Andrew Wylie, declined comment.













Roth certainly produced, completing more than 20 novels over half a century and often turning out one a year. He won virtually every prize short of the Nobel and wrote such classics as “American Pastoral” and “Portnoy’s Complaint.”


His name will remain on new releases, if only because the Library of America has been issuing hardcover volumes of his work. Roth also is cooperating with award-winning biographer Blake Bailey on a book about his life.


The author chose an unexpected forum to break the news, but he has been hinting at his departure for years. He has said that he no longer reads fiction and seemed to say goodbye to his fictional alterego, Nathan Zuckerman, in the 2007 novel “Exit Ghost.”


Retirement is rarely the preferred option for writers, for whom the ability to tell stories or at least set down words is often synonymous with life itself. Poor health, discouragement and even madness are the more likely ways literary careers end. Roth apparently is fit and his recent novels had been received respectfully, if not with the awe of his most celebrated work.


“I don’t believe it,” Roth’s friend and fellow writer Cynthia Ozick said upon learning the news. “A writer who stops writing while still breathing has already declared herself posthumous.”


His parting words from “Nemesis”: “He seemed to us invincible.”


Roth’s interview appeared in French and has been translated, roughly, by The Associated Press. He tells Les inRocks that “Nemesis” was “mon dernier livre” (“My last book”) and refers to “Howard’s End” author E.M. Forster, and how he quit fiction in his 40s. Roth said he doesn’t plan to write a memoir, but will instead go through his archives and help ensure that Bailey’s biography comes out in his lifetime.


Explaining why he stopped, Roth said that at age 74 he became aware his time was limited and that he started re-reading his books of the past 20-30 years, in reverse order. He decided that he agreed with what the boxer Joe Louis had said late in life, that he had done the best he could with what he had.


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California teen steps into rattlesnake nest, survives
















SAN DIEGO (Reuters) – A teenage California girl searching for a cell phone signal to call her mother in a rural area outside San Diego inadvertently stepped into a nest of rattlesnakes and was bitten six times, but survived.


The 16-year-old, Vera Oliphant, spent four days in the intensive care unit of Sharp Grossmont Hospital, and doctors gave her 24 vials of antivenom after she was bitten by an adult rattlesnake and five young rattlers outside her uncle’s home.













“I was trying to find a signal to call my mom and text my boyfriend,” Oliphant said on Friday, a day after she was released from the hospital following the October 27 incident.


“I didn’t see them until I already stepped on their nest and I felt them biting me.”


“My vision started to go right away. First it looked like the snakes blended into the leaves and then I started seeing black spots around the edges and I started blacking out.”


She returned to her uncle’s home in Jamul, outside San Diego, and he immediately packed her into the car and rushed her to the emergency room, she said.


On the way, she talked to her mom and her boyfriend, who told her to stay calm so the venom wouldn’t spread.


“I told my mom and my boyfriend I love them in case I don’t get to see them again,” she said.


Doctors there administered 24 vials of antivenom to quash the dangerous toxins, according to a hospital spokesman. Snakebites usually aren’t fatal, although a handful of people die in the United States each year from snake bites, including bites from rattlesnakes.


Oliphant has recovered and will be returning to classes at Chaparral High School in El Cajon on Monday. She said the next time she can’t get a signal, she will handle it differently.


“Be careful where you step,” she said. “If you don’t need to, just wait until you are somewhere that you can call people.”


(Editing By Cynthia Johnston and Todd Eastham)


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Lockheed boss resigns over affair

















US defence company Lockheed Martin says its incoming president and chief executive officer has resigned over a relationship with a subordinate.













Christopher Kubasik resigned after an internal ethics investigation confirmed the “close personal relationship”, the company said in a statement.


He was due to take over as head of the company next year after serving as its chief operating officer.


Another Lockheed executive, Marillyn Hewson, will now become CEO in January.


Chairman and outgoing CEO Robert Stevens said he was “deeply disappointed and saddened” by the relationship, which he described as “inconsistent with our values and standards”.


But he said the company had a “strong leadership team and a robust succession plan”.


Lockheed Martin is a defence and aerospace company based in Maryland that employs some 120,000 worldwide.


Its net sales for 2011 were $ 46.5bn (£29bn).


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Syria opposition bloc elects Christian as leader
















DOHA, Qatar (AP) — Syria‘s main opposition group in exile has elected a Christian Paris-based former geography teacher as its new president.


George Sabra said Friday that his election as head of the Syrian National Council is a sign that the opposition is not plagued by sectarian divisions.













Sabra says the SNC‘s main demand is to receive weapons from the international community. The U.S. and some other foreign backers of rebels fighting the regime of President Bashar Assad have so far refused to send weapons for fear they can fall into the wrong hands.


Middle East News Headlines – Yahoo! News



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Dancing With The Stars Family Rallies On Twitter In Support Of Brooke Burke-Charvet Following Thyroid Cancer Diagnosis
















Members of the “Dancing with the Stars” family Tweeted their well-wishes for the show’s co-host, Brooke Burke-Charvet, who revealed on Thursday she has thyroid cancer.


Helio Castroneves, who was recently eliminated from the “All-Stars” season, said he is confident she will overcome the disease.













PLAY IT NOW: Brooke Burke-Charvet’s Sexy Lingerie Shoot!


“Hi @brookeburke, I have sure that you will win this battle. My affection for you,” the Indy driver wrote.


Brooke revealed on Thursday that she will be undergoing thyroid surgery and a thyroidectomy, and Erin Andrews, who competed in Season 10, noted she was praying for the host.


VIEW THE PHOTOS: The Lovely Brooke Burke-Charvet


“Thinking about @DancingABC friend @brookeburke..Prayers and all the best your way Brooke,” Erin wrote.


Also sending her kind words was Sabrina Bryan, who was eliminated last week on the show.


“@brookeburke hey girl!! You’re in my thoughts and prayers! Always here for you during this fight! Stay strong,” Sabrina wrote.


VIEW THE PHOTOS: Dancing With The Stars: All-Stars — Week 6


Season 13 vet Ricki Lake wrote, “@brookeburke sending huge healing love your way.”


Current contender Melissa Rycroft shared her support, Tweeting, “You’re such a strong woman, and I admire your courage. I hope you feel all the love and support behind you…We love you!”


VIEW THE PHOTOS: ‘Dancing’s’ Derek Hough


And some of the professional dancers chimed in too.


Pro Derek Hough (Brooke’s Season 7 partner) Tweeted, “Love you Brookie B. [You're] in my prayers.”


Cheryl Burke Tweeted, “I love u @brookeburke!! Stay strong. Will be praying for u and sending u lots of positive energy!”


– Jolie Lash


Copyright 2012 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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VP Joe Biden guest stars as celebrity crush on “Parks and Rec”
















LOS ANGELES (Reuters) – Someone has a big crush on U.S. Vice President Joe Biden – and now she is getting to meet him.


Biden will make his TV acting debut with a cameo on NBC‘s comedy “Parks and Recreation” as the celebrity crush of actress Amy Poehler‘s ditzy local councilwoman Leslie Knope, NBC said on Thursday.













Biden, 69, will play himself in the episode “Leslie vs. April,” airing November 15, where Knope, a city councilwoman for the fictional small town of Pawnee, Indiana, has a surprise meeting with the vice president in Washington D.C.


Knope has long described her ideal man as having the “brains of George Clooney and the body of Joe Biden.”


“Meeting Vice President Biden was a thrill for me and for Leslie,” Poehler said in a statement.


“He was a good sport and a great improviser. The vice president maintained his composure while I harassed him and invaded his personal space. The nation of ‘Parks and Rec’ will be forever grateful,” she added.


The scenes with Biden were shot in July in the chambers of the vice president’s ceremonial office, during the TV show’s recent trip to the nation’s capital to film scenes for this season’s storylines.


The biggest challenge of landing Biden’s cameo was keeping it a secret before Tuesday’s U.S. elections. Airing the episode prior to November 6 could have been equivalent to a campaign contribution to advertise a candidate, executive producer Michael Schur told Entertainment Weekly.


“Parks and Recreation” follows the Pawnee Parks department and its tireless deputy Knope, who puts all her efforts into improving her little hometown.


This is a big season for Poehler’s character, who is finally elected into city government, gets engaged to campaign advisor Ben Wyatt and meets her political heroes including Senators Barbara Boxer, Olympia Snow and John McCain, who were featured in September’s season premiere.


(Reporting By Piya Sinha-Roy, editing by Jill Serjeant)


TV News Headlines – Yahoo! News



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